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EC number: 200-521-5
CAS number: 61-82-5
Mallards received amitrole at nominal dietary concentrations of 95, 156
and 256 ppm a.i. at intervals during a two generation reproduction
study. The F0 generation was exposed to treated diets from
photostimulation through an egg laying cycle of seven weeks and selected
F1 offspring were exposed to treated diets for the first eight weeks of
rearing. The F1 offspring were exposed to treated diets for an
eight-week period during grow-out and were paired and exposed to
appropriate treated diets again at approximately 45 weeks of age and
monitored through a six week reproduction cycle. F2 hatchlings were
reared to 14-days of age on untreated diet. Due to the impact of the
test substance upon mallards in the 156 and 256 ppm a.i. treatment
groups for the F0 generation, 10 pairs of mallards from each of those
groups were transferred to untreated diet for a five week withdrawl (W)
phase. Offspring from those birds (F1W) were handled comparably to the
F1 exposure phase birds.
No impact upon growth or reproductive success was noted at the 95 ppm
a.i. test concentration. Multiple, and typically concentration
responsive, effects were noted upon growth and reproduction at the 156
and 256 ppm a.i. test concentrations, including the corresponding
withdraw groups. At all necropsy intervals, primarily concentration
responsive impacts upon thyroid gland size were noted at the 95, 156 and
256 ppm a.i. concentrations. The reproductive no-observed-effect
concentration was 95 ppm a.i., approximately equivalent to a calculated
average daily dietary dose of 16 mg/kg bw/day during the exposure phases.
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