Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 235-252-2
CAS number: 12141-20-7
The number of chromatid or chromosome aberrations did not increase with
lead treatment except for chromatid gaps at 0.5 or 1% lead acetate. No
change in the frequency of micronuclei was observed in mice treated with
lead in the diet or by intraperitoneal injection.
Female mice (10 per group) were fed diets containing 0, 0.25, 0.5, or 1%
lead acetate for one month, and another group of 5 mice received 0.25%
lead acetate for three months. Bone marrow was collected and examined
for chromosome or chromatid aberrations. Additional female mice (n=10)
received two intraperitoneal injections of 25 mg/kg lead at 24-hour
intervals and were sacrificed 30 hours after the second injection for
the micronucleus test. The micronucleus test was also performed on mice
that received 0.25% lead in the diet for one month. The number of
chromatid or chromosome aberrations did not increase with lead treatment
except for chromatid gaps at 0.5 or 1% lead acetate. No change in the
frequency of micronuclei was observed in mice treated with lead in the
diet or by intraperitoneal injection. The authors suggest that lead
appears to have no genetic action, except for the increase in chromatid
gaps, which, in their opinion, does not have any genetic consequence.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again