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EC number: 235-252-2
CAS number: 12141-20-7
The number of chromatid or chromosome aberrations did not increase with
lead treatment except for chromatid gaps at 0.5 or 1% lead acetate. No
change in the frequency of micronuclei was observed in mice treated with
lead in the diet or by intraperitoneal injection.
Female mice (10 per group) were fed diets containing 0, 0.25, 0.5, or 1%
lead acetate for one month, and another group of 5 mice received 0.25%
lead acetate for three months. Bone marrow was collected and examined
for chromosome or chromatid aberrations. Additional female mice (n=10)
received two intraperitoneal injections of 25 mg/kg lead at 24-hour
intervals and were sacrificed 30 hours after the second injection for
the micronucleus test. The micronucleus test was also performed on mice
that received 0.25% lead in the diet for one month. The number of
chromatid or chromosome aberrations did not increase with lead treatment
except for chromatid gaps at 0.5 or 1% lead acetate. No change in the
frequency of micronuclei was observed in mice treated with lead in the
diet or by intraperitoneal injection. The authors suggest that lead
appears to have no genetic action, except for the increase in chromatid
gaps, which, in their opinion, does not have any genetic consequence.
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