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EC number: 235-252-2
CAS number: 12141-20-7
The lowest NOEC for mammals refers to a full chronic study for mammals
(Morris et al. 1938), which resulted in a NOEC value of 64 mg Pb/kg ww.Sub-chronic
and chronic studies for 3 different mammal species were collected from
literature, ie for Rattus sp. (different strains), Rattus norvegicus and
for mice. For mammal oral toxicity the values varied between 64 and
>12800 mg/kg ww. The lowest value of 64 mg Pb/kg ww was used to derive
the PNEC, which was observed in several experiments with the
Osborn-Mendel rat. According to the guidance, the PNECoral was
calculated from the lowest NOECoral using an assesment factor.
An assessment factor of 6 has been selected on the lowest toxicity data.
Considering a background concentration of 1.3 mg Pb/kg in the food, the
PNECoral can be calculated as:PNECoral= (NOEC +Cb)/AF =
(64+1.3)/6 =10.9 mg/kg food (mammal). This value is further used
for risk characterisation purposes.
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