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EC number: 235-252-2
CAS number: 12141-20-7
This study assessed the in vitro absorption of lead oxide in human skin
samples at 0, 111, and 1033 ug/cm2 concentrations over 24 hours. For the
111 ug/cm2 dose, 95.63% of the applied lead was removed during the wash
at 6 hours post-exposure. At 24 hours post-exposure, 99.51% of the
applied dose was not absorbed. The absorbed dose into the receptor fluid
was <0.01% (5 ng/cm2) and the dermal delivery was 0.13% (148 mg/cm2) of
the applied dose. For the 1033 ug/cm2 dose, 96.10% of the applied lead
was removed during the wash at 6 hours post-exposure. At 24 hours
post-exposure, 98.28% of the applied dose was not absorbed. The absorbed
dose was <0.01% (10 ng/cm2) and the dermal delivery was 0.05% (479
ng/cm2) of the applied dose. The authors concluded that the apparent
decrease in absorption as a function of dose may be attributable to the
considerable background from endogenous lead in the donor skin
restricting the reliability of the absorption factor at the low dose.
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