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EC number: 235-252-2
CAS number: 12141-20-7
The aim of the present experiment was to obtain information on the acute
toxicity following single 4 -hour inhalation exposure of rats to
Litharge (Lead Oxide) in an acute toxicity study designed as a test
limit. Rats were exposed to a dust of Litharge (Lead oxide) at an actual
concentration of 5.05 +/-0.010mg Litharge/L air for 4 hours by
inhalation using a dynamic nose-only exposure chamber. In the inhalation
chamber, close to the animals' noses, the particles had a mass median
aerodynamic (MMAD) of 5.834UM as determined with a cascade impactor. The
Geometric Standard Deviation (GSD) of the MMAD was calculated as 4.814.
The geometric mean diameter of the supplied test item was 11.430 um as
determined with a Malvern Mastersizer. Under the present test
conditions, a 4-hour exposure to a dust of Litharge (lead oxide at a
concentration of 5.05 +/-0.10 mg Litharge/L air revealed no clinical
signs of toxicity. No mortality occurred. No abnormalities were detected
at necropsy. All animals gained the expected weight throughout the study
period. The LC50 can be expected above an actual concentration of 5.05
mg Litharge/L air for 4 hours at 14 days. According to the EC-Commission
directive 67/548/ECC and its subsequent amendments on the approximation
of the laws, regulations, and administrative provision relating to the
classification, packaging and labelling of dangerous substances and the
results obtained under the present test conditions. Litharge (Lead
oxide) requires no classification under CLP.
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