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EC number: 235-252-2
CAS number: 12141-20-7
Lead oxide is a non-irritant.
The purpose of this study was to assess irritant and/or corrosive
effects of LITHARGE lead oxide on eyes and associated mucous membranes
following ocular administration to rabbits. Information derived from
this test serves to indicate the existence of possible hazards likely to
arise from exposure of the eye to the test substance.
The potential toxicity of LITHARGE lead oxide was assessed in an acute
eye irritation/corrosion test on 3 albino rabbits. In each animal, 0.1g
of the test article was introduced into the conjunctival sac of the
right eye, the untreated left eye served as control. Both eyes were
examined at 1, 24, 48 and 72 hours post applicationem. The following
results were obtained:
Between 24 and 72 hours after instillation no ocular findings were seen.
The only finding was slight redness of the conjunctivae in one animal 1
h after instillation.
No general toxic effects were observed.
The mean grades of ocular reactions 24, 48 and 72 hours after
instillation were "0" in each animal.
The test substance was classsified according to the EEC directive
2001/59/ECC of 6 August 2001 and the Gefahrstoffverordnung (GefStoffV)
of 15 November 1999 (BGB1. I, p. 2233). When administered to the eye,
the test substance LITHARGE lead oxide may therefore be classified as
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