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EC number: 235-252-2
CAS number: 12141-20-7
In the VRAL (LDAI, 2008) 12 feeding studies with birds (7 bounded NOECs)
have been selected. An update of that database was made with 2
additional studies for birds (1 bounded NOEC). Sub-chronic and chronic
studies for 4 different bird species were collected from literature, ie
for Gallus domesticus, Gallus sp., Colinus virginianus (Bobwhite quail)
and Coturnix japonica (Japanese quail). For birds oral toxicity the
values varied between 100 and 2000 mg/kg ww. The lowest value of 100 mg
Pb/kg ww was used to derive the PNEC, which was observed in several
experiments with Japanese quails after 12 weeks. According to the
guidance, the PNECoral was calculated from the lowest NOECoral using an
An assessment factor of 6 has been selected on the lowest toxicity data.
Considering a background concentration of 1.3 mg Pb/kg in the food, the
PNECoral can be calculated as: PNECoral = (NOEC +Cb)/AF =
(100+1.3)/6 = 16.9 mg/kg food (birds).
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