Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 235-252-2
CAS number: 12141-20-7
In the VRAL (LDAI, 2008) 12 feeding studies with birds (7 bounded NOECs)
have been selected. An update of that database was made with 2
additional studies for birds (1 bounded NOEC). Sub-chronic and chronic
studies for 4 different bird species were collected from literature, ie
for Gallus domesticus, Gallus sp., Colinus virginianus (Bobwhite quail)
and Coturnix japonica (Japanese quail). For birds oral toxicity the
values varied between 100 and 2000 mg/kg ww. The lowest value of 100 mg
Pb/kg ww was used to derive the PNEC, which was observed in several
experiments with Japanese quails after 12 weeks. According to the
guidance, the PNECoral was calculated from the lowest NOECoral using an
An assessment factor of 6 has been selected on the lowest toxicity data.
Considering a background concentration of 1.3 mg Pb/kg in the food, the
PNECoral can be calculated as: PNECoral = (NOEC +Cb)/AF =
(100+1.3)/6 = 16.9 mg/kg food (birds).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again