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EC number: 235-252-2
CAS number: 12141-20-7
On the basis of the results obtained after a single dermal
administration of the test article "LITHARGE lead oxide" to Wistar rats,
the LD50 values after 24 h and 14 days were as follows: Male and female
> 2000 mg/kg
The acute dermal toxicity of LITHARGE lead oxide was investigated in one
group of rats comprising 5 males and 5 females. On the basis of the
range finding test, the animals were given a single dermal
administration of LITHARGE lead oxide at the dose of 2000 mg/kg. The
skin was exposed to the test articles for 24 hours. Clinical
observations were carried out at regular intervals during the 14 -day
observation period. Signs of erythema and oedema were evaluated once
daily for 14 days. Body weights were determoned immediately before
treatment and on days 7 and 14 p.a. Gross pathological examinations were
carried out at study termination on all animals. The following results
- No animal died during the 14 -day observation period.
- No abnormal clinical signs were observed.
- No signs of or skin iiritation were observed.
- The body weight development was slightly influenced in most animals
during the first week after treatment, possibly due to the
administration procedure as such. At the end of the study, 14 days after
treatment, the body weights were in the normal range
-Gross pathological examinations on day 14 p.a. did not reveal any
findings in the rats.
Since no deaths were caused in Wistar rats after dermal treatment with
the test article LITHARGE lead oxide of 2000mg/kg, the LD50 values after
24h and 14 days were as follows: Male and Female >2000 mg/kg
The above value is higher than the limit specified as harmful by the EEC
Directive 2001/59/EEC of 6 August 2001 and the Gefahstoffverordnung
(GedStoffV) of 15 November 1999 (BGB1.I, p. 2233). When administered by
the dermal route, the test article LITHARGE lead oxide may therefore be
classified as "non-toxic".
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