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EC number: 235-252-2
CAS number: 12141-20-7
There were no differences in feed consumption as a function of dose
level for any of the test chemicals.
Groups of male Fischer-344 rats (10 rats/group) were exposed to feed
containing either 0, 10, 30, or 100 ppm lead (in the form of lead
acetate, lead oxide, lead sulfide, or Alaskan lead ore concentrate) for
30 days. Relative bioavailability of lead was assessed by measuring
cumulative lead uptake in femur bone and excretion of
delta-aminolevulinic acid (ALA) in urine on day 23 of exposure. Lead
concentration was also measured in blood samples taken prior to exposure
on day 0 and during exposure on days 7, 14, and 21. The authors reported
substantial contamination of blood samples and stated that no
conclusions could be made from the blood lead data in this study. The
authors concluded that diets containing lead acetate and lead oxide
provided sufficient lead in bioavailable form to cause increases in
urinary ALA, and that the lead in the diets containing lead sulfide and
the Alaskan lead ore concentrate was either not absorbed or was absorbed
in a form not available for biochemical interactions normally associated
with the toxic effects of lead. They also concluded that, based on the
uptake of lead into femurs, bioavailability was highest for lead
acetate, intermediate for lead oxide, and lowest for lead sulfide and
Alaskan lead ore concentrate. Femur uptake of lead was linearly related
to dose for each compound studied, and lead uptake did not exhibit a
feedback mechanism in the range of doses administered in this study.
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