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EC number: 235-252-2
CAS number: 12141-20-7
The acute oral toxicity of "LITHARGE lead oxide was investigated
according to ATC method in one step using 3 male and 3 female rats.
Three female animals were given a single oral administration of the test
article Litharge lead oxide at a dose of 2000 mg/kg. Clinical
observations were carried out at regular intervals during the 14-day
observation period. Body weights were determined immediately before
treatment and on 7 days and 14 p.a. Gross pathological examinations were
carried out immediately at termination on all animals.
The following results were obtained:
-No animals died during the course of the 14-day observation period
following the dose of 2000 mg/kg.
-No abnormal clinical signs were observed
-There was no influence of the treatment on the body weight development
in all male and female animals during the 14-day observation period.
-Gross pathological examinations on day 14 p.a. did not reveal test
According to the EEC Directive 2001/59, 6 August 2001 and the
Gefahrstoffverordnung (GefStoffV) of 15 November 1999 (BGB1. I, p.2233),
the test article LITHARGE lead oxide can be classified as "non-toxic",
since the oral LD50 value after 24 h and 14 days is expected to be
higher than 2000 mg/kg in male and female Wistar rats.
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