Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-688-8
CAS number: 2867-47-2
Summary of the test results:
Time of sacrifice: 24 hours after the 2ndadministration
Time of sacrifice: 48 hours after the 2ndadministration
*** = P<0.001
Vehicle: physiological solution (0.9% NaCl)
PE: polychromatic erythrocytes
NE: normochromatic erythrocytes
MPE/PE: micronucleated polychromatic erythrocytes/2000
SD: standard deviation
The study was performed according to OECD TD 473 in compliance with GLP.
Swiss OF1/ICO:OF1 IFFA-CREDO mice (5 males and 5 females per group)
received two administrations separated by 24 hrs of 200 mg/kg bw TS by
the intraperitoneal route. The application of the vehicle (0.9% NaCl
solution) served as negative control, cyclophosphamide at 25 mg/kg bw
(two-times i.p. injection) served as the positive control. The test
animals were killed 24 or 48 hrs after the 2nd administration and bone
marrow smears were examined for the presence of micronuclei in 2000
polychromatic erythrocytes (PE) per mouse and for the PE/NE ratio. The
number of micronucleated polychromatic cells (MPE) in the dosed animals
was not significantly different from that of the animals in the control
groups. The PE/NE ratio did not differ from that of the respective
vehicle control group.
Conclusion: The TS did not induce cytogenetic damage to the bone marrow
cells of mice when treated twice separated by 24 hrs by intraperioneal
route at 200 mg/kg in the micronucleus test.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again