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EC number: 220-688-8
CAS number: 2867-47-2
In a well-conducted study, the substance induced severe erythema, oedema
and necrosis 24 h after application. For all animals, the maximum score
of 4 was noted for erythema and oedema. The reactions persisted to 72
In a well conducted study, severe corneal, iris and conjuctival lesions
were displayed within 2 hours of instillation. The study was
terminatined after 2 h. It is reasonable to assume, that similar level
of injury would be induced if full scale testing would be conducted.
Therefore, the substance is judged as eye corrosive.
Individual skin responses:
Re-evaluation of the skin irritation test with 2-dimethylaminoethyl
Remark: Consideration of shaved/intact skin readings only
There are three reports available. Among these, the study by Atochem was
identified as the key study because it was conducted according to the
recommendations of the Federal Hazardous Substances Labelling Act
Regulations, Section 191.11, published in the Federal Register (USA)-29
FR13009, 1964 (Atochem, 1980). The test substance was administrated to
the intact and abraded skin of New-Zealand albino rabbits at the dose
level of 0.5 mL per animal under an occlusive patch for 24 hours. The
cutaneous reactions were observed just after the removal of the patch
and after 72 hours. Severe erythema, oedema and necrosis were observed
after the test, and these symptoms persisted to the inspection after 72
hours of the test. The obtained primary irritation score was 8.0. Under
these test conditions, the test substance was considered to be corrosive
to the skin.
In a second study in rabbits according to the method of Draize the test
substance was considered to be highly irritating to the skin (Roehm,
1977). The test substance furthermore tested on the skin of guinea pigs
resulting in highly irritating effects (Roehm, 1977).
The only study available was considered to be reliable because it was
conducted in accordance with the recommendations of the Federal
Hazardous Substances Labelling Act (Atochem, 1980). Severe cornea, iris
and conjunctivae lesions were displayed in both rabbits within 2 hours
after the instillation of 0.l mL undiluted test substance into the eye.
The test substance was considered to be corrosive to the eyes.
According to Annex VI of EC/1272/2008 (CLP-regulation), the
test substance is classified as irritating to skin (Skin Irrit 2, H315)
and irritating to eyes (Eye Irrit 2, H319). However, based on the
results of two skin irritation studies in rabbits (Atochem, 1980; Roehm,
1977) and one eye irritation study in rabbits (Atochem, 1980), the test
substance is considered to be corrosive to skin and eyes. Therefore, the
following classification of the test substance is suggested
GHS classification according to Annex I of EC/1272/2008:
- Skin Corr 1B, H314
- Eye Dam1, H318
- Respiratory irritation: No classification required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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