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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study with restrictions (non-GLP, no details on test substance incl. purity, 48-hour reading missing, short observation period).

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1980
Reference Type:
publication
Title:
Atochem (1980), Skin and Ocular Irritation test, Consultox Lab: CL80 65:2030
Author:
Atochem
Year:
2003
Bibliographic source:
cited in: OECD SIDS, 2-Dimethylaminoethylmethacrylate, CAS No: 2867-47-2, 07/2003

Materials and methods

Principles of method if other than guideline:
According to the method described in the Federal Hazardous Substances Labelling Act Regulations, Section 191.11, published in the Federal Register - 29 F.R. 13009, 1964.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
No details.

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals and environmental conditions:
No details.

Test system

Type of coverage:
occlusive
Preparation of test site:
other: intact (shaved) and abraded
Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
TEST MATERIAL
- Amount applied: 0.5 ml
- Concentration: undiluted
Duration of treatment / exposure:
24 hours
Observation period:
72 hours
Number of animals:
4
Details on study design:
A 0.5 mL sample of the test material was applied to areas of intact and abraded areas of skin. These areas were then occluded with square surgical gauge patches, each measuring 1 inch x 1 inch. After 24 hrs exposure, the patches were removed and the resulting reactions evaluated. The valuation was done again at 72 hrs.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
24/48/72 h
Score:
4
Max. score:
4
Reversibility:
other: not examined
Remarks on result:
other: Observation period too short for a clear conclusion on reversibility.
Remarks:
Only time point 24 and 72 hours were observed.
Irritation parameter:
edema score
Basis:
mean
Time point:
24/48/72 h
Score:
4
Max. score:
4
Reversibility:
other: not examined
Remarks on result:
other: Observation period too short for a clear conclusion on reversibility.
Remarks:
Only time point 24 and 72 hours were observed.
Irritant / corrosive response data:
Severe erythema, oedema and necrosis were exhibited 24 hrs following application. Reactions persisted to 72 hrs. For all animals and for both of
intact skin and abraded skin, maximum score of 4 was marked in the erythema and oedema rating, therefore a Primary Irritation Score of 8.0 was obtained.

Any other information on results incl. tables

Individual skin responses:

 

Rabbit No.

Time

(hours)

Intact Skin

Abraded Skin

Erythema

Oedema

Erythema

Oedema

1

24

4

4

4

4

72

4

4

4

4

2

24

4

4

4

4

72

4

4

4

4

3

24

4

4

4

4

72

4

4

4

4

4

24

4

4

4

4

72

4

4

4

4

5

24

4

4

4

4

72

4

4

4

4

6

24

4

4

4

4

72

4

4

4

4

Mean

24

4

4

4

4

72

4

4

4

4

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information
Conclusions:
The test material is considered to be corrosive to the skin.