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EC number: 220-688-8
CAS number: 2867-47-2
For 2-dimethylaminoethyl methacrylate, a GLP OECD Guideline 204 study on
prolonged toxicity to fish is reported. After 14 days of exposure in a
semi-static system a LC50 of 5.26 mg/L was measured. The LC0 after 14
days was determined at 2.96 mg/L. However, according to Annex IX
long-term toxicity tests on fish shall provide information about one of
the following parameters: a) early-life stage toxicity; b) short-term
toxicity on embryo and sac-fry stages or c) juvenile growth inhibition.
Thus, the present prolonged study cannot be taken into account for a
long-term toxicity assessment; therefore, the result of this study can
just be used for a pre-evaluation of the long-term toxicity of the test
substance. Furthermore, analytical monitoring showed that a major part
of the test substance was degraded within 24 hours. Investigations on
abiotic degradation showed that over time the substance will hydrolyse
under environmental conditions into methacrylic acid (CAS# 79-41-4) and
2-dimethylamino ethanol (CAS# 108-01-0). Therefore, the mortality was
probably caused by degradation products too. An investigation on
long-term toxicity is just reported for methacrylic acid. The result of
this OECD Guideline 210 study showed a NOEC of 10 mg/L.
In addition, in Annex IX of Regulation (EC) No 1907/2006, it is laid
down that long-term toxicity to fish shall be proposed by the registrant
if the chemical safety assessment indicates the need to investigate
further the effects on fish. According to Annex I of this regulation,
the chemical safety assessment triggers further action when the
substance or the preparation meets the criteria for classification as
dangerous according to Directive 67/548/EEC or Directive 1999/45/EC or
is assessed to be a PBT or vPvB.
The hazard assessment of 2-dimethylaminoethyl methacrylate reveals
neither a need to classify the substance as
dangerous to the environment, nor is it a PBT or vPvB substance,
nor are there any further indications that the substance may be
hazardous to the environment. Therefore, and for reasons of animal
welfare, a long-term toxicity study in fish is not provided.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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