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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Remarks:
Original report is only available in Japanese. The translation is in progress. Therefore, the report is cited by a peer-reviewed OECD SIDS.

Data source

Referenceopen allclose all

Reference Type:
other: summary report
Title:
Unnamed
Year:
1998
Reference Type:
publication
Title:
Toxicity Testing Reports of Envirmnmental Chemicals vol. 6, p. 539-568
Author:
Ministry of Health and Welfare, Japan
Year:
2003
Bibliographic source:
cited in: OECD SIDS, 2-Dimethylaminoethylmethacrylate, CAS No: 2867-47-2, 07/2003

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
2-dimethylaminoethyl methacrylate
EC Number:
220-688-8
EC Name:
2-dimethylaminoethyl methacrylate
Cas Number:
2867-47-2
Molecular formula:
C8H15NO2
IUPAC Name:
2-(dimethylamino)ethyl methacrylate
Test material form:
liquid
Specific details on test material used for the study:
TEST MATERIAL:
Name of test material: 2-(dimethylamino)ethyl methacrylate

Test animals

Species:
rat
Strain:
other: Crj:CD(SD)
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Doses:
0 (Vehicle), 500, 1000, 2000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
yes
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
not determinable due to absence of adverse toxic effects
Mortality:
No deaths occurred in any of the treated groups.
Gross pathology:
At necropsy, raised patches in the forestomach were observed in males of the 2000 mg/kg group.
Other findings:
Histopathologically, papillomatous hyperplasia in the forestomach was apparent.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Executive summary:

A single oral toxicity study revealed a LD50 value of above 2000 mg/kg bw for the substance in both sexes.