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Diss Factsheets

Administrative data

Endpoint:
short-term repeated dose toxicity: dermal
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary source available.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Morphological changes of rabbit skin by application of Dentine Primer
Author:
Manabe A et al.
Year:
1990
Bibliographic source:
Dent. Mater. J., 9 (2), 147-152
Reference Type:
secondary source
Title:
Manabe. A. et al., Morphological changes of rabbit skin by application of Dentine Primer, Dent. Mater. J., 9 (2), 147-152, 1990
Author:
Manabe A. et al.
Year:
2003
Bibliographic source:
cited in: OECD SIDS, 2-Dimethylaminoethylmethacrylate, CAS No: 2867-47-2, 07/2003

Materials and methods

Principles of method if other than guideline:
Subacute dermal toxicity study in rabbits. Twice per day 50 µl of undiluted test substance were applied to the sheared rabbit skin for 7 days, followed by a 7-day post-exposure period.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-dimethylaminoethyl methacrylate
EC Number:
220-688-8
EC Name:
2-dimethylaminoethyl methacrylate
Cas Number:
2867-47-2
Molecular formula:
C8H15NO2
IUPAC Name:
2-(dimethylamino)ethyl methacrylate
Test material form:
liquid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Details on exposure:
TEST SITE
- Area of exposure: sheared skin

TEST MATERIAL
- Amount applied: 30 µl
Duration of treatment / exposure:
7 days
Frequency of treatment:
twice per day
Control animals:
yes
Details on study design:
- Post-exposure recovery period: 7 days

Results and discussion

Results of examinations

Details on results:
Important morphological change (coagulation, necrosis, oedema and little cell infiltration) of the dermis. High irritation due to 2-propenoic acid, 2-methyl, dimethylaminoethylester is not reversible 7 days after the end of treatment. Systemic effects were not reported.

Effect levels

Dose descriptor:
NOAEL
Remarks on result:
not determinable
Remarks:
no NOAEL identified

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion