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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
Original report is not available. However, the report is cited by a peer-reviewed OECD SIDS.
Qualifier:
according to
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
GLP compliance:
yes
Analytical monitoring:
yes
Vehicle:
no
Test organisms (species):
Daphnia magna
Details on test organisms:
TEST ORGANISM
- Common name: water flea
- Source: National Institute for Environmental studies (Japan)
- Age at study initiation (mean and range, SD): < 24 h
- Feeding during test: no
Test type:
semi-static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Hardness:
30.3 mg/L
Test temperature:
19.7 - 20 °C
pH:
7.52 - 7.67
Dissolved oxygen:
8.43 - 8.93 mg/L
Nominal and measured concentrations:
Test concentrations (nominal): 18, 32, 56, 100, 180 and 320 mg/L
Test concentrations (measured): 10.5, 18.7, 29.7, 43.7, 70.4 and 119 mg/L
Details on test conditions:
TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: 100 mL test solution in 100 mL glass beaker
- Renewal rate of test solution (frequency/flow rate): every 24 h renewal of the test solution
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4


OTHER TEST CONDITIONS
- Photoperiod: 16:8 h light-darkness cycle
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
33 mg/L
Nominal / measured:
meas. (arithm. mean)
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
48 h
Dose descriptor:
NOEC
Effect conc.:
18.7 mg/L
Nominal / measured:
meas. (arithm. mean)
Conc. based on:
test mat.
Basis for effect:
mobility

Measured concentrations of MADAME:

Nominal conc. (mg/L)

Measured conc. (mg/L)

Percent of nom.

0 h (new)

24 h (old)

Mean

Control

N.D.

N.D.

N.D.

-

18

15

7.33

10.5

58

32

30.1

11.6

18.7

58

56

51.7

17.0

29.7

53

100

76.2

25.0

43.7

44

180

145

34.2

70.0

39

320

285

49.4

119

37

Mortality:

Nominal conc. (mg/L)

 

 

24 h

48 h

Control

0

0

18

0

0

32

0

0

56

0

4

100

6

20

180

12

20

320

20

20

Description of key information

2-dimethylaminoethyl methacrylate is acute harmful to aquatic invertebrates.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
33 mg/L

Additional information

The acute toxicity of 2-dimethylaminoethyl acrylate to aquatic invertebrates was investigated in two studies. The MOE Japan (1997) reported an EC50 (48h) of 33 mg/L to Daphnia magna using a semi-static test system according to OECD guideline 202. In the second study an EC50 (48 h) of 53 mg/L was measured using the same species. Based on the results it can be concluded that with high probability 2-dimethylaminoethyl methacrylate is acute harmful to aquatic invertebrates.