Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Sensitisation data (human)

Currently viewing:

Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
other: case reports
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Method and results sufficient described. Bias-positive: patients of dermatologists or dermal clinics are a cohort preselected for having a problem with the skin. Cross-reactions to other (meth)acrylates not suspended. Only 2 individuals tested.

Data source

Reference
Reference Type:
publication
Title:
Occupational methacrylate and acrylate allergy from glues.
Author:
Aalto-Korte K, Alanko K, Kuuliala O, Jolanki R
Year:
2008
Bibliographic source:
Contact dermatitis Vol. 58, No. 6: 340-6

Materials and methods

Type of sensitisation studied:
skin
Study type:
case report
Principles of method if other than guideline:
case reports, patch test
10 patients exposed to acrylic glues with occupational contact dermatitis examined during the years 1994 - 2006, sensitivity to acrylates and methacrylates were diagnosed. The patch tests were performed with (meth)acrylate series (Chemotechnique) using the Finn Chambers (Epitest, Tuusula, Finland) according to the recommendations of the International Contact Dermatitis Research Group. The tests were read 2 or 3 times on D2-(D3)-D4/5/6 depending on the day of their application. The test vehicle was petrolatum.

GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-dimethylaminoethyl methacrylate
EC Number:
220-688-8
EC Name:
2-dimethylaminoethyl methacrylate
Cas Number:
2867-47-2
Molecular formula:
C8H15NO2
IUPAC Name:
2-(dimethylamino)ethyl methacrylate
Details on test material:
Purity not specified, but commercial grade assumed.

Method

Type of population:
other: patients with dermatitis with previous contact with (meth)acrylate (acrylic glues)
Subjects:
- Number of subjects: 2 patients with suspected contact allergy were patch tested
Route of administration:
dermal
Details on study design:
A retrospective appraisal of 473 patch test records from September 1994 to August 2006 at the Finnish Institute of Occupational Health was  made. 61 patients had allergic reactions to at least one allergen. Of these, 32 patients working in dental professions have been reported previously (Aalto-Korte k et al. (2007) Contact Dermatitis 57: 324-330). The files of 10 patients showed present occupational exposure to acrylic glues.

Results and discussion

Results of examinations:
473 patients with a history of exposure to (meth)acrylates were identified. 39 (meth)acrylates were tested in 10 to 473 of these individuals. All 10 individuals showed at least one relevant reaction. For N,N-Dimethylaminoethyl methacrylate, 2 individuals were tested at a patch test concentration of 
0.2 % in pet.(w/w). Of these 2 (occupationally exposed and sensitised to acrylic glues) individuals, 1 showed a positive reaction to DMAEMA.

Applicant's summary and conclusion

Conclusions:
For N,N-Dimethylaminoethyl methacrylate, 2 individuals who had contact allergy to methacrylates or acrylates and had used acrylic glues at work were tested at a patch test concentration of 0.2 % (w/w) in petrolatum. Of these 2 individuals, 1 showed a positive reaction in respect of DMAEMA.
Executive summary:

For N,N-Dimethylaminoethyl methacrylate, 2 individuals who had contact allergy to methacrylates or acrylates and had used acrylic glues at work were tested at a patch test concentration of 0.2 % (w/w) in petrolatum. Of these 2 individuals, 1 showed a positive reaction in respect of DMAEMA.