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EC number: 220-688-8
CAS number: 2867-47-2
The oral toxicity of Dimethylaminoethyl methacrylate (CAS 2867 -47 -2,
Purity: 99.79%) when given by daily administration to rats, has been
investigated over a period of 13 consecutive weeks and recovery from any
treatment-related effects during a treatment-free period of 4 weeks.
Three groups, each of 10 male and 10 female Sprague Dawley rats,
received the test item by gavage at dosages of 100, 200 and 500
mg/kg/day for 13 consecutive weeks. A fourth similarly constituted group
received the vehicle alone (corn oil) and acted as a control. Additional
five male and 5 female animals were included in separate groups for
neuropathology investigations. Control and high dose main and
neuropathology groups included each 5 additional animals per sex to be
sacrificed after 4 weeks of recovery.
Minor signs of possible treatment-related effects of the test item,
Dimethylaminoethyl methacrylate, were observed at in vivo and at post
mortem in male and female rats only at the dose levels of 200 and 500
mg/kg/day, when administered by oral gavage for 13 consecutive weeks at
the dosages of 100, 200 and 500 mg/kg/day. None of them were considered
to be systemically adverse.
No changes indicating a neuropathological effect of the treatment with
the test item were observed at any of the dose levels tested.
No significant changes were observed in the animals dosed at 100
Therefore, the high dose of 500 mg/kg/day, when administered daily
for 13 consecutive weeks, was considered the No Observed Adverse Effect
Level (NOAEL) for systemic long-term toxicity.
is acceptable and
guideline requirement for a 13 week oral toxicity study
(OECD 408) in rats.
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