Registration Dossier
Registration Dossier
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EC number: 205-565-9 | CAS number: 142-84-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In vitro studies:
Dipropylamine was evaluated for mutagenicity in the Salmonella/microsome preincubation assay using a standard protocol approved by the National Toxicology Program. Dipropylamine doses of 0, 33, 100, 333, 1000 and 3333 µg/plate were tested in four Salmonella typhimurium strains (TA98, TAl00, TAl535 and TAl537) in the presence and absence of Aroclor-induced rat or hamster liver S9. These tests were negative and the highest ineffective dose level tested in all four Salmonella tester strains under all treatment conditions was 3333 µg/plate. (Zeiger et al. 1988; Val. 2).
Short description of key information:
In vitro studies:
Ames-Test: negative (NTP standard protocol)
In vivo studies:
No valid data available.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
A valid Ames-tests, with or without metabolic activation through S9-Mix, failed to provide any evidence for a mutagenic effect of Dipropylamine. Test substance is not warranted for classification.
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