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Key value for chemical safety assessment

Additional information

In vitro studies:

Dipropylamine was evaluated for mutagenicity in the Salmonella/microsome preincubation assay using a standard protocol approved by the National Toxicology Program. Dipropylamine doses of 0, 33, 100, 333, 1000 and 3333 µg/plate were tested in four Salmonella typhimurium strains (TA98, TAl00, TAl535 and TAl537) in the presence and absence of Aroclor-induced rat or hamster liver S9. These tests were negative and the highest ineffective dose level tested in all four Salmonella tester strains under all treatment conditions was 3333 µg/plate. (Zeiger et al. 1988; Val. 2).

Short description of key information:
In vitro studies:
Ames-Test: negative (NTP standard protocol)

In vivo studies:
No valid data available.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

A valid Ames-tests, with or without metabolic activation through S9-Mix, failed to provide any evidence for a mutagenic effect of Dipropylamine. Test substance is not warranted for classification.