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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
23. Sep 1969 - 26. Sep 1969
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented report which meets basic scientific principles.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1969
Report date:
1969

Materials and methods

Principles of method if other than guideline:
BASF-Test, see details in remarks on material and methods.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Dipropylamine
EC Number:
205-565-9
EC Name:
Dipropylamine
Cas Number:
142-84-7
Molecular formula:
C6H15N
IUPAC Name:
N-propylpropan-1-amine
Details on test material:
- Name of test material (as cited in study report): di-n-propylamine
- Physical state: liquid

Test animals / tissue source

Species:
rabbit
Strain:
other: Russians
Details on test animals or tissues and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 2.7 and 3.0 kg

Test system

Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 50 µl
Duration of treatment / exposure:
single application, eyes were not washed out.
Observation period (in vivo):
3 days
Number of animals or in vitro replicates:
2

Results and discussion

In vivo

Results
Irritation parameter:
cornea opacity score
Remarks:
; corrosion
Basis:
mean
Time point:
other: 24 h - 48 h - 72 h
Score:
4
Max. score:
4
Reversibility:
not reversible

Any other information on results incl. tables

The application of the test substance caused after 10 minutes severe corrosion predominantly expressed by severe corneal opacity. Therefor a precise evaluation of erythema, chemosis and iritis scores was not possible. Due to severe effects the test was terminated after 72 h. Severe corneal opacity is considered to be an irreversible effect to ophthalmic tissue.

Applicant's summary and conclusion

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