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EC number: 205-565-9
CAS number: 142-84-7
Irritation:- skin: corrosive- eye: corrosive
In a primary skin irritation study with undiluted dipropylamine,
exposure of 1 min caused after 24 h full thickness necrosis and was not
reversible within the 8 day observation period (BASF AG 1969;
reliability score 2). In a newer studies 3 min and already
1minapplication dipropylamine produced dermal corrosion at all sites
exposed to the test article (Hoechst, 1989 and 1993; Val. 2). The dermal
response was initially characterized by necrosis and progressed to
eschar after 1 h in 2/3 rabbits and 3/3 rabbits 24 h postdose. The
eschar persisted throughout the remainder of the seven day study.
Corrosive effects of undiluted test substance to skin were found in
three other studies where only limited data is provided (Union Carbide,
1957; Val. 2; Eastman Kodak, 1955 / Dow Chemical, 1973; Val. 4).
In a primary eye irritation study in rabbits, 50 µL of the test
substance caused severe corrosion predominantly expressed by corneal
opacity. Due to these severe and irreversible effects the test was
terminated after 72 h. (BASF AG 1969;Val. 2). In a newer study the eye
irritation potential of dipropylamine was evaluated in 4 rabbits
administered 0.1 ml undiluted doses into right eyes, the left eyes
serving as negative control. The treated eyes remained unrinsed and were
evaluated for signs of irritation up to 7 days post-instillation.
Responses were profound and included corneal opacity, stippling and
ulceration to prevent grading of iritis in 3 rabbits at 24th hour
evaluation. Severe conjunctival irritation in all 4 animals was
characterized by redness, chemosis, discharge, and/or ulceration. Humane
intervention terminated study for the 3 worst effected animals after
24th hour evaluation. Upon Day 7 examination, the remaining rabbit
continued to exhibit corneal opacity, stippling, and pannous with
moderate-severe conjunctival irritation and iridic changes (Hoechst,
1989; Val. 2). Three further studies confirmed these severe corrosive
effects (Union Carbide, 1957; Val. 2; Eastman Kodak, 1955 / Dow
Chemical, 1973; Val. 4).
EU classification according to
Annex I of Directive 67/548/EEC: C; R35
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