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EC number: 205-565-9
CAS number: 142-84-7
Significant accumulation in organisms is not
to be expected.
In Article 13 of Regulation (EC) No
1907/2006, it is laid down that information on intrinsic properties of
substances may be generated by means other than tests, provided that the
conditions set out in Annex XI (of the same Regulation) are met.
Furthermore, according to Article 25
of the same Regulation testing on vertebrate animals shall be undertaken
only as a last resort.
According to Annex XI of Regulation
(EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific
validity of the (Q)SAR model has been established, (2) the substance
falls within the applicability domain of the (Q)SAR model, (3) the
results are adequate for the purpose of classification and labeling
and/or risk assessment and (4) adequate and reliable documentation of
the applied method is provided.
For the assessment of dipropylamine
(CAS 142 -84 -7) (Q)SAR results were used for aquatic bioaccumulation.
The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are
considered to be adequately fulfilled and therefore the endpoint(s)
sufficiently covered and suitable for risk assessment.
Therefore, and for reasons of animal
welfare, further experimental studies on aquatic bioaccumulation are not
No studies are available for the
bioaccumulation assessment of the substance. According to Regulation
(EC) 1907 (2006) Annex IX, Section 9.3.2, Column 2, a study on
bioaccumulation does not need to be conducted as the substance has a low
potential for bioaccumulation. Dipropylamine (CAS 142 -84 -7) has an
experimentally determined log Kow of 1.33 (23 °C,; BASF AG, 1987; rep.
no.: BRU 87.261, see IUCLID Ch. 4.7). Regarding these values,
accumulation of the test substance in organisms is not to be expected.
Therefore, and for reasons of animal welfare, a study on bioaccumulation
is not provided.
In order to assess the bioaccumulation
potential of the substance, the BCF was calculated with several
Considering all models applied for the
substance, the estimated BCF values range from 3.5 to 19 L/kg. The
substance was within the applicability domain of all estimation models.
A BCF calculation using the BCF base-line model v04.11 (OASIS CATALOGIC
v.5.14.1) is available. The model estimated a BCF of 19 L/kg without
considering mitigation factors. But, metabolism, water solubility and,
for a minor part, molecular size reduce the BCF to 3.5 L/kg as estimated
by the model. The substance is to 100% within the applicability domain
of the model (BASF SE, 2020).
- BCFBAF v3.01 (EPI Suite v4.11):
Based on the measured log Kow of 1.33 (BASF AG, 1987), a BCF value of
3.5 L/kg was estimated with the submodel Meylan et al. (1997/1999). This
BCF estimate can be regarded as accurate as the compound was within the
applicability of the model, indicating that significant bioaccumulation
in organisms is not to be expected.
- T.E.S.T. v4.2.1 (US EPA, 2016): The
model is validated using statistical external validation using separate
training and test data sets. The Consensus method averages the
reasonable results from all applicable methods of T.E.S.T.: hierarchical
clustering, single model, group contribution, FDA, and nearest neighbor.
Regarding CAS 142 -84 -7, the predicted BCF values range from 1.7 to 9.6
L/kg. The Consensus method resulted in a BCF of 5.7 (BASF SE, 2020). The
confidence in the results is high and the substance is within the
applicability domain of the model. This applies to the external test set
as well as to the training set.
- VEGA v1.1.3 Meylan v1.0.3: The BCF
is estimated based on the calculated log Kow of: 1.65 (calculated by
VEGA: Meylan/KOWWIN). The BCF value was predicted to be 6 L/kg. The
substance was within the Applicability Domain; therefore, the result
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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