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EC number: 205-565-9
CAS number: 142-84-7
Adsorption to solid soil phase is not
expected. Moreover, the substance is readily biodegradable.
Article 13 of Regulation (EC) No 1907/2006, it is laid down that
information on intrinsic properties of substances may be generated by
means other than tests, provided that the conditions set out in Annex XI
(of the same Regulation) are met.
to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used
if (1) the scientific validity of the (Q)SAR model has been established,
(2) the substance falls within the applicability domain of the (Q)SAR
model, (3) the results are adequate for the purpose of classification
and labeling and/or risk assessment and (4) adequate and reliable
documentation of the applied method is provided.
the assessment of dipropylamine (CAS 142 -84 -7)(Q)SAR
results were used for the estimation of the adsorption potential. The
criteria listed in Annex XI of Regulation (EC) No 1907/2006 are
considered to be adequately fulfilled and therefore the endpoint(s)
sufficiently covered and suitable for risk assessment.
further experimental studies on the adsorption potential are not
According to Regulation (EC) No 1907/2006,
Annex VIII, Section 9.3.1, Column 2, the study on adsorption/desorption
screening does not need to be conducted if based on the physicochemical
properties the substance can be expected to have a low potential for
adsorption (e.g. the substance has a low octanol water partition
coefficient), or the substance and its relevant degradation products
decompose rapidly. The substance is readily biodegradable according to
OECD criteria (OECD 301B, BASF AG, 2005; see IUCLID Ch. 5.2.1). In
addition, the substance has a log Kow of 1.33 (at 23 °C, see IUCLID Ch.
4.7). Therefore, a study does not need to be conducted.
assess the adsorption potential of dipropylamine (CAS 142 -84 -7) no
experimental data exist. Therefore, the Koc value was estimated using a
environmentally relevant conditions, dipropylamine will
be present in its ionised form (pKa = 11; at 20 °C, cited in HSDB database,
see IUCLID Ch. 4.21). Therefore, the adsorption coefficient was
calculated according to Franco & Trapp (2008, 2009, 2010) to correct for
the charged molecule at pH 5, 7, and 8. This pH range is representative
for 98% of the European soils. The substance is within the applicability
domain of the model. The Koc values of the Franco & Trapp method give a
good indication on the adsorption potential of a substance depending on
the pH conditions of soil. The method is based on the dissociation
constant pKa and the log Kow for the uncharged molecule. The resulting
Koc at pH 5 to 7 is 282 L/kg and the log Koc is 2.45, respectively, at
pH 8 the resulting Koc is 1325 L/kg, and the log Koc is 3.12.
It can be concluded, that adsorption to
solid soil phase is not expected at environmentally relevant conditions. Moreover,
the substance is readily biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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