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EC number: 205-565-9 | CAS number: 142-84-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 Oct 1969 - 23 Oct 1969
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
- Principles of method if other than guideline:
- BASF-Test, see details in remarks on material and methods.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Dipropylamine
- EC Number:
- 205-565-9
- EC Name:
- Dipropylamine
- Cas Number:
- 142-84-7
- Molecular formula:
- C6H15N
- IUPAC Name:
- dipropylamine
- Details on test material:
- - Name of test material (as cited in study report): Di-n-propylamin
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: water with traganth
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 4 % - Doses:
- 800, 640, 500 and 400 ml/kg bw = 592, 474, 370 and 290 mg/kg bw (coversion in mg/kg bw is based on the density of 0.74 g/cm3)
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations: several times on the day of exposure and daily thereafter
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 495 mg/kg bw
- 95% CL:
- 428 - 566
- Remarks on result:
- other: coversion in mg/kg bw is based on the density of 0.74 g/cm3
- Mortality:
- See details in remarks on results.
- Clinical signs:
- other: Intermittent respiration, dyspnoe, ruffled fur, squatting posture, calmness, trembling gait, watery mouth discharge.
- Gross pathology:
- No abnormalities observed.
Any other information on results incl. tables
Mortality:
| Dose (mg/kg bw) | Gender | 1 h | 24 h | 48 h | 7 days | ||||||
| 592 | male | 0/5 | 4/5 | 4/5 | 4/5 | ||||||
| 592 | female | 0/5 | 4/5 | 4/5 | 4/5 | ||||||
| 474 | male | 0/5 | 3/5 | 3/5 | 3/5 | ||||||
| 474 | female | 0/5 | 1/5 | 1/5 | 1/5 | ||||||
| 370 | male | 0/5 | 0/5 | 0/5 | 0/5 | ||||||
| 370 | female | 0/5 | 1/5 | 1/5 | 1/5 | ||||||
| 290 | male | 0/5 | 0/5 | 0/5 | 0/5 | ||||||
| 290 | female | 0/5 | 0/5 | 0/5 | 0/5 |
The test substance caused toxicity (including mortality) in a dose dependent manner, after a single ingestion.
Applicant's summary and conclusion
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