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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
16 Oct 1969 - 23 Oct 1969
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented report which meets basic scientific principles.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1969
Report date:
1969

Materials and methods

Principles of method if other than guideline:
BASF-Test, see details in remarks on material and methods.
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Dipropylamine
EC Number:
205-565-9
EC Name:
Dipropylamine
Cas Number:
142-84-7
Molecular formula:
C6H15N
IUPAC Name:
N-propylpropan-1-amine
Details on test material:
- Name of test material (as cited in study report): Di-n-propylamin

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: water with traganth
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 4 %
Doses:
800, 640, 500 and 400 ml/kg bw = 592, 474, 370 and 290 mg/kg bw (coversion in mg/kg bw is based on the density of 0.74 g/cm3)
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations: several times on the day of exposure and daily thereafter
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
495 mg/kg bw
95% CL:
428 - 566
Remarks on result:
other: coversion in mg/kg bw is based on the density of 0.74 g/cm3
Mortality:
See details in remarks on results.
Clinical signs:
Intermittent respiration, dyspnoe, ruffled fur, squatting posture, calmness, trembling gait, watery mouth discharge.
Body weight:
No data
Gross pathology:
No abnormalities observed.

Any other information on results incl. tables

Mortality:

Dose (mg/kg bw) Gender  1 h  24 h  48 h  7 days          
592  male  0/5  4/5 4/5  4/5        
592  female 0/5  4/5 4/5  4/5          
474  male  0/5  3/5 3/5  3/5          
474  female  0/5  1/5 1/5 1/5          
370  male  0/5  0/5  0/5  0/5          
370 female   0/5  1/5  1/5  1/5          
290  male  0/5  0/5  0/5  0/5          
290  female  0/5  0/5  0/5  0/5          

The test substance caused toxicity (including mortality) in a dose dependent manner, after a single ingestion.

Applicant's summary and conclusion

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