Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable report which meets basic scientific principles.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unnamed
Year:
1962
Reference Type:
study report
Title:
Unnamed
Year:
1957

Materials and methods

Principles of method if other than guideline:
See details in remarks on material and methods.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Dipropylamine
EC Number:
205-565-9
EC Name:
Dipropylamine
Cas Number:
142-84-7
Molecular formula:
C6H15N
IUPAC Name:
N-propylpropan-1-amine
Details on test material:
- Name of test material (as cited in study report): Di-n-propylamine

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 2.5 - 3.5 kg
- Diet (e.g. ad libitum): Rockland rabbit diet

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 h
Doses:
0.625, 1.25 and 2.5 ml/kg bw (462.5, 925 and 1850 mg/kg bw; conversion in mg/kg bw is based on the density d=0.74 g/cm3)
No. of animals per sex per dose:
4 (males only)
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
925 mg/kg bw
95% CL:
622 - 1 369
Remarks on result:
other: conversion in mg/kg bw is based on the density d=0.74 g/cm3
Mortality:
1850 mg/kg bw: 4/4, within 24 h
925 mg/kg bw: 2/4, one animal on day 1 and on day 5 posttreatment
462.5 mg/kg bw: 0/4
Clinical signs:
no data
Body weight:
Surviving animals lost weight.
Gross pathology:
Necrosis of the skin resulted from the covered application. Internal organs of victims appeared pale or opaque. This may have been caused by the corrosive action of the compound on these organs. Only the lung among the 6 that died had hemorrhaged. All others looked normal.

Applicant's summary and conclusion

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