Registration Dossier

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

The substance is acutely harmful to aquatic invertebrates.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
58 mg/L

Additional information

To assess the short-term toxicity of dipropylamine (CAS 142-84-7) towards aquatic invertebrates, read-across was performed to the structurally similar substances diethylamine (CAS 109-89-7). Under supervision of the Japanese Ministry of the Environment a Daphnia magna immobilisation test according to OECD 202 was conducted under GLP and published in 2000. The daphnids were exposed for 48 hours under static conditions to nominal test concentrations of 0.79 to 15.0 mg/L diethylamine. In addition, in a supplemental test, test concentrations of 27.0 to 157.5 mg/L were tested. The test concentrations were analytically verified and deviated more than 20% from the nominal test concentrations. Therefore, measured geomean concentrations were used to assess the effect values. A 48 -h EC50 was determined to be 58 mg/L (95% CL: 49.9 - 68.1 mg/L, based on measured geomean concentrations; NITE 2000).

In addition, a study is available for dipropylamine (CAS 142 -84 -7) itself. The effects of dipropylamine on the acute toxicity to aquatic invertebrates were investigated in a non GLP-study according to EU Method C.2, under semi-static conditions. As test organism Daphnia magna was used. The 48 -h EC50 value was determined to be 73.3 mg/L (nominal, BASF AG, 1988. report no.: 1/0010/2/88-0010/88).

The test concentrations were not analytically verified, therefore, it is not considered for the environmental risk assessment as a key study.

In conclusion, dipropylamine is acutely harmful to aquatic invertebrates.

Categories Display