Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-565-9
CAS number: 142-84-7
Repeated dose toxicity: oralNOAEL: 300 mg/kg bw/day
In the available subacute study (14-day feeding; Virginia
Chemical Inc., 1975) conducted similar to the OECD Guideline 407
(Repeated Dose 28-Day Oral Toxicity in Rodents; with some deviations: no
heamatology, clinical chemistry, urinanalysis, neurobehavioural
examination, ophthalmoscopic examination and water consumption; no data
on analytical verification of doses), the test substance was
administered in the diet to 3 groups of 10 animals per sex (albino rats)
at dosage levels of 75, 150 and 300 mg/kg bw per day (an additional
control group received the basal diet).
All animals survived the 2-weeks treatment. Patterns of
appearance and behavior were not remarkable in any of the treated groups
throughout the study. Gross observations at necropsy and subsequent
microscopic examinations of liver and kidney sections of all animals
revealed no evidence of compound-related tissue alterations in any of
the treated groups.
Slight dose-related decreases in the rates of body weight
gain were observed in the male and female treated groups at week 1 and
in the male treated groups at week 2. The weight gain of the high-dose
males was approximately 20% less than that of the control gain.
Mean food consumption values were also slightly lower at
week 1 and 2 in the treated male animals than in the control group,
suggesting that the high-dose animals reached an unpalatability
Based on the subacute study available, there is no need for
classification for repeated dose toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Deze website maakt gebruik van cookies om het surfen zo aangenaam mogelijk te maken.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again