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EC number: 931-335-9
CAS number: 90622-74-5
study was performed to assess the eye irritation potential of the test
substance, C12 -18 and C18 -unsatd. DEA, according to OECD Guideline 405
and EU Method B.5, in compliance with GLP. Four rabbits received 0.01 mL
of an undiluted solution in one eye. The other eye remained untreated.
After 1, 6, 24, 48 and 72 h, then 7, 10, 14, 17 and 21 d, eyes were
analysed for reaction based on the Draize scoring method. On the cornea,
slight to moderate opacity was observed in all treated eyes. The
reaction was irreversible. Irreversible effects were also noted in the
iris of one animal. Finally, all animals presented moderate to severe
redness, chemosis, and/or exudation (sometimes infiltrated with blood)
of the conjunctivae, which did not entirely disappear by the end of the
21 d observation period. Under the study conditions, the test substance
was highly irritating to the rabbit eye (Kästner, 1987).
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