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EC number: 931-335-9
CAS number: 90622-74-5
study was conducted to assess the skin irritation potential of the test
substance, C12-18 and C18-unsatd. DEA, to rabbit skin according to OECD
Guideline 404 and EU Method B.6, in compliance with GLP. The shaved skin
of 5 rabbits was exposed to the undiluted test substance using occlusive
patches for 4 h. The skin was then observed for effects (scoring
according to the Draize system) for 21 d after patch removal. Exposure
to undiluted test substance caused light to moderate erythema and light
oedema immediately after removal of the patch. The reactions intensified
until the 72 h observation time point when strong erythema and moderate
to strong oedema, as well as eschar formation were seen. No or only
traces of the eschar were left in 1/5 and 4/5 animals, respectively,
after 21 d. The acute reactions were no longer visible after 14 d. Under
the study conditions, the test substance was considered to be irritating
to rabbit skin (Kästner, 1986).
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