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EC number: 931-335-9
CAS number: 90622-74-5
study was conducted to determine the acute dermal toxicity of the test
substance, C8-18 and C18-unsatd. DEA, in male/female New Zealand White
rabbits. The procedure was the modification of the techniques described
in Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics,
compiled by the staff of the Division of Pharmacology, Food and Drug
Administration. A single dose of 2000 mg/kg bw of test substance was
applied to the abraded and intact skin of the test animals. The trunk of
each animal was then encased in a sleeve of plasticized material for a
24 h period. Animals were observed immediately after dosing, and at 1, 6
and 24 h post-dosing. Following the 24 h exposure period, animals were
observed for mortality, skin response and general behaviour for 14 d. No
mortality occurred. All animals appeared normal throughout the 24 h
exposure and 14 d post-exposure observation periods. Under the study
conditions, the dermal LD50 in rabbits was found to be > 2000 mg/kg bw
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