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EC number: 931-335-9
CAS number: 90622-74-5
A study was conducted to evaluate the
repeated dose oral toxicity of the test substance, C12-18 and
C18-unsatd. DEA, according to design based on OECD guideline 407. Groups
of 10 male and 10 female Wistar rats were orally gavaged with the
substance diluted in olive oil, 5 d/week for 28 d at doses of 0, 70,
250, 750 (Days 1-14) and 1500 (Days 15-28) mg/kg bw/d. Clinical signs,
bodyweight, haematology, clinical chemistry, urinalysis, gross and
microscopic pathology were recorded. Additional groups of 5 male and 5
female rats were kept for a 4 month recovery period. No
treatment-related adverse effects were observed at any of the doses.
Changes in the forestomach at some doses including controls were
attributed to the use of olive oil and found to be reversible after end
of exposure. Under the study conditions, the 28 d NOAEL to rats was
considered to be >750 mg/kg bw/day (Potokar, 1983).
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