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Physical & Chemical properties

Solubility in organic solvents / fat solubility

Administrative data

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
July 26, 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study was conducted equivalent or similar to EU test Method A.6
Justification for data waiving:
other:
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report Date:
2010

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
other: EU test method L383 A/54-62 (EEC A.6)
Deviations:
no
Principles of method if other than guideline:
The flask method is used for determination of 1-octanol solubility. In this method, the substance dissolved in 1-octanol at a temperature somewhat above the test temperature. When saturation is achieved the mixture is cooled and kept at the test temperature, stirring as long as necessary to reach equilibrium. Subsequently, the mass concentration of the substance in the supernatant aqueous solution, which must not contain any undissolved particles, is determined by a suitable analytical method.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): C-SAT 100029
- Lot/batch No.: #CA00450001

Results and discussion

Solubility in organic solvents / fat solubility
Medium:
n-octanol
Remarks:
1-octanol
Solubility:
other: cannot be determined because the test material is mixable in 1-octanol in all proportions
Remarks on result:
other: Test material is mixable in 1-octanol in all proportions
Test substance stable:
not determined
Details on results:
The test material is mixable with 1-octanol in all proportions

Any other information on results incl. tables

Preliminary test:

For this purpose, 0.1 g of the test material was melted and weighed in and 0.1, 0.5, 1.0, 2.0 and 10.0 g of 1-octanol were added to each weighted sample. The test material was completely solved giving clear solutions.

Applicant's summary and conclusion

Conclusions:
Under the test conditions, 1-octanol solubility cannot be determined because amides, C12-18(even-numbered) and C18(unsatd.), N,N-bis(hydroxyethyl) is mixable in 1-octanol in all proportions
Executive summary:

Determination of 1-octanol solubility of amides, C12-18(even-numbered) and C18(unsatd.), N,N-bis(hydroxyethyl) was performed by applying similar experimental conditions described for determination of water solubility according to test procedure VTA34N00003.01, which complies with EU test method A.6.

Under the test conditions, 1-octanol solubility cannot be determined because the amides, C12-18(even-numbered) and C18(unsatd.), N,N-bis(hydroxyethyl) is mixable in 1-octanol in all proportions.