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EC number: 931-335-9
CAS number: 90622-74-5
For detailed results and bar charts kindly
refer to the attached background materials section of the IUCLID.
A study was conducted to evaluate the in
vivo genetic toxicity of the test substance, C8-18 and C18-unsatd. DEA
(48 -56% active) according to the method recommended in the First
Addendum to OECD Guideline 474 and Method No. 431, Annex V of EEC
Directive 79/831. The experimental animals were 70 NMRI mice, divided
into 5 groups. Of the 5 groups, 3 were test groups, 1 negative control
group and 1 positive control group. The test groups were treated with
15000 mg test substance/kg bw, the negative control group with distilled
water and the positive control group with 30 mg cyclophosphamide/kg bw.
The mice were killed 24, 48 and 72 h, respectively, after treatment.
From bone marrow smears, micronucleus counts were made per 1000
polychromatic erythrocytes. The test substance did not induce an
increase in the frequency of micronucleated normochromatic erythrocytes
in peripheral blood samples from both male and female mice. Under the
study conditions, the test substance did not induce an increase in the
frequency of micronuclei in bone marrow cells of the mouse, and was
therefore considered to be non-mutagenic (Kallesen, 1985).
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