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EC number: 931-335-9
CAS number: 90622-74-5
A study was conducted to evaluate the dermal
absorption of (14C) radiolabelled N,N-bis(2-hydroxyethyl)dodecanamide
(LDEA) in B6C3F1 mice. Four male mice were exposed to a single dose of
50, 100, 200 or 800 mg/kg bw of the substance placed on a 1x1 inch
surface of previously clipped skin, covered with a non-occlusive patch.
After 72 h of exposure, gauzes and aliquots of urine, faeces, dermal
rinse solutions and digested skin samples (in 2N ethanolic sodium
hydroxide) were collected and analysed for radiochemical content by
liquid scintillation counting. After 72 h of exposure, 50 to 70% of the
applied doses were absorbed and there were no statistically significant
differences in absorption across the range of doses. The disposition of
substance in the tissues was similar across the four dose levels
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