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EC number: 203-396-5
CAS number: 106-42-3
The study identified 500 mg/m3
as a NOAEL for effects on foetal survival and foetal malformations or
variation for rabbits.
The embryotoxic effects of mixed
xylene and the o- , p- and m- xylene isomers were investigated in mice,
rats and rabbits following a method similar to the OECD Guideline 414
(Prenatal Developmental Toxicity Study) Guideline.
Groups of CFY rats were exposed to the
inhalation of mixed xylene at 250, 1900 or 3400 mg/m3 for 24h
day from day 7 - 15 of gestation. CFLP mice and NZ rabbbits were exposed
to inhalation of 500 mg/m3 ortho-, meta- , para- xylene and
500 or 1000 mg/m3 mixed xylene for 24h/day from gestation
days 6 - 15. Untreated animals served as controls, which inhaled pure
Mixed xylene and all the xylene
isomers crossed the placenta and were found present in foetal blood and
amniotic fluid. Maternal toxic effects at all solvent concentrations
were moderate and dose- dependent. Mixed xylene increased post-
implantation loss in rats. Mortality was observed in rats at 3400 mg/m3
(3.4 mg/L) mixed xylene and at 100 mg/m3 (0.1 mg/L) para-
xylene and xylene in rabbits. No mortality was observed in mice exposed
to mixed xylene or any of the xylene isomers. Mixed xylene and xylene
isomers at 1000 mg/m3 (1 mg/L) decreased maternal weight gain
in rabbits and increased the number of foetal losses by abortion. A
significant percentage of dead or resorbed foetus were seen in rats at
3400 mg/m3 mixed xylene.
In terms of foetal effects, the
highest concentrations of mixed xylene (≥3400 mg/m3 =
13% (p<0.05) in rats caused a decrease in the body weight in male
foetuses. Mixed xylene and all xylene isomers increased the incidence of
weight retarded foetuses in mice, especially at the higher
concentrations. When mixed xylene and xylene isomers were tested at 1000
mg/m3 in rabbits, they caused a decrease in the weight of
female foetuses and exposure at 500 mg/m3 caused a moderate
embryotoxic effect where there was an increased incidence of weight
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