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EC number: 203-396-5
CAS number: 106-42-3
The lowest result is a 24 hour EC50 of 1 mg/L for o-xylene. (Galassi 1988, o-xylene). The estimated LL50 values from TLM QSAR were 8.730 - 11.076 mg/L.
The experimental value was used for chemical safety assessment.
Data are available on the acute toxicity of
each of the xylene isomers to aquatic invertebrates. The study by
Galassi et al (1988) follows OECD 202 and uses Daphnia magna,
whilst Holcombe et al (1987) used a flow through system to expose
different species (including Daphnia magna) simultaneously.
Niederlehner et al (1998) used Ceriodaphnia dubia as the test
organism. All studies included analytical confirmation of the exposure
The 24 and 48 hour EC50 results reported
from these studies for the different isomers are very similar, with a
range of 1-4.7 mg/L. In the study by Niederlehner et al (1998) the
highest concentration tested did not result in effects on mortality, so
the EC50 is >3.4 mg/L. The most conservative result from the individual
isomers will be used in the risk assessment, which is the 24 hour EC50
of 1 mg/L for o-xylene. (Galassi 1988)
A TLM-EqP modeling framework was used to
support values derived experimentally and are presented as supporting
The estimated LL50 values from TLM QSAR were
8.730 - 11.076 mg/L
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