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EC number: 203-396-5
CAS number: 106-42-3
Exhaled breath data shows an initial
absorption phase with steady state exhaled breath concentration 1 hour
after dermal dose application and a peak exhaled breath concentration of
approximately 30 ppb. Variability in data likely reflects temporary
variations in breathing rates and any movement by the animal.
Male F344 rats were dermally exposed to
aqueous o-xylene. O-xylene absorption was measured using real-time
exhaled breath analysis together with physiologically based
pharmacokinetic (PBPK) modelling. The calculated rat skin permeability
coefficient K(p) was 0.058 +/- 0.009 cm/h.
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