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EC number: 203-396-5 | CAS number: 106-42-3
Toxicity to terrestrial plants
Administrative data
Link to relevant study record(s)
Description of key information
A weight of evidence (WoE) approach was utilised as an alternative to ‘long term testing on plants’ endpoint as it is believed that the proposed study alone is unlikely to produce reliable or repeatable toxicity results due to the rapid volatilisation of xylenes from soil. QSARs supported by relevant, reliable and robust existing data from experimental studies and from literature are used to fill this endpoint.
The TLM-EqP predicted effected values for Avena sativa were 56.759 - 191.263 mg/kg soil dw for short term (14 day LL50) and 10.873 - 36.640 mg/kg soil dw for long-term effects (21 day NOELR), respectively.
The TLM-EqP predicted effected values for Brassica rapa were 36.646 - 123.490 mg/kg soil dw for short term (14 day LL50) and 7.020 - 23.657 mg/kg soil dw for long-term effects (21 day NOELR), respectively.
Key value for chemical safety assessment
- Short-term EC50 or LC50 for terrestrial plants:
- 36.646 mg/kg soil dw
- Long-term EC10, LC10 or NOEC for terrestrial plants:
- 7.02 mg/kg soil dw
Additional information
Due to the technical challenges of testing volatile substances, a TLM-EqP modeling framework was used to support terrestrial effect values derived experimentally and are presented as supporting studies. These data were considered reliable and comparable to experimentally derived values; however, were not used in the PNEC derivation in order to comply with ECHA FDL (2014) on using experimental data to derive PNEC. The hazard to soil organisms was assessed by using the experimental data. The TLM-EqP predicted effected values for Avena sativa were 56.759 - 191.263 mg/kg soil dw for short term (14 day LL50) and 10.873 - 36.640 mg/kg soil dw for long-term effects (21 day NOELR), respectively.
The TLM-EqP predicted effected values for Brassica rapa were 36.646 - 123.490 mg/kg soil dw for short term (14 day LL50) and 7.020 - 23.657 mg/kg soil dw for long-term effects (21 day NOELR), respectively.
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