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EC number: 203-396-5
CAS number: 106-42-3
Simple reaction time: No significant
differences between exposure conditions (although differences were
obtained both as a result of day sequence and of varying times of day).
Memory reproduction: No significant differences between exposure
conditions (although significant improvements in performance were found
that related both to day sequence and to time of day when the analysis
was performed on the number of correctly reproduced elements). Choice
reaction times: No significant differences between exposure conditions.
Heart rate: No significant differences between exposure conditions.
Subjective symptoms: No differences between exposure conditions. Most
subjects (12 of 16) succeeded in identifying the control condition. Only
a few were able to distinguish between the various solvent conditions.
Sixteen male volunteers were exposed to a
series of solvents including 300 mg/m3 p-xylene for 4 hours
and simple reaction time, short term memory and choice reaction time and
subjective symptoms assessed. Performance of the tests together with
reporting of subjective symptoms did not differ between the control and
p-xylene-exposed conditions. The results indicate that 300 mg/m3
p-xylene is without measurable effect on selected human CNS functions.
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