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EC number: 203-396-5
CAS number: 106-42-3
of male and female CD rats were exposed to 0, 60, 250, or 500 ppm mixed
xylenes (groups I, II, III, and IV, respectively by inhalation. exposure
was for 6 hours per day, 5 days per week, for 131 days prior to and
during mating, with exposure continued in females on gestation days 1–20
and lactation days 5–20. Two additional 500 ppm groups were similarly
exposed, except that only the F0 males were exposed in group V, and only
the F0 females were exposed in group VI. In-life parameters evaluated in
adults included body weights, observations for mortality and clinical
signs, detailed weekly physical examination, maternal body weights and
maternal food consumption and food efficiency. One-half of all F0 males
were sacrificed after the mating period for gross post mortem
examination; the remaining half were sacrificed and examined following a
21 day treatment-free period.
Litters were standardized by pooling all
pups within each treatment group on lactation day 4 and redistributing
(where possible) four males and four females from this pool to each dam.
Pups were weighed, sexed, and given a gross external examination on
lactation days 1, 4, and 21. Randomly selected pups from each group
(one/sex/litter) and all remaining F0 females with litters were
sacrificed on day 21 of lactation and subjected to gross necropsy. The
remaining pups were maintained for the postweaning interval of 28–49
days and weighed and sacrificed on day 49. Randomly selected pups from
each group (one/sex/litter) were given a complete gross postmortem
The highest exposure level of 500 ppm mixed
xylene administered for 6 hours per day for 131 days prior to mating,
during mating and continuing through gestation and lactation is a NOAEC.
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