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EC number: 203-396-5
CAS number: 106-42-3
are available for all three xylene isomers from GLP-compliant guideline
studies (Dr Noack 2015). The studies followed OECD guideline 301F (ready
biodegradability: manometric respirometry test) using a mixture of
sewage and soil micro-organisms. m-xylene reached 60% biodegradation
after 5 days and 98% biodegradation after 28 days. o-xylene reached 60%
biodegradation after 8 days and 94% biodegradation after 28 days.
p-xylene reached 60% biodegradation after 7 days and 90% biodegradation
after 28 days. The studies show that the xylene isomers are readily
biodegradable, meeting the 10 day window criterion.
three xylene isomers are considered readily biodegradable on the basis
of the results of the GLP-compliant studies (Dr Noack 2015). Several
additional studies are available for xylene isomers showing ready
biodegradability, as well as QSAR estimates and further studies showing
high levels of biodegradation. The available evidence has been used to
conclude that all the xylene isomers are considered to be readily
et al. (1998) showed that 50% o- and p-xylene applied to soil were
mineralised in 23 and 13 days, respectively, in a study following a
method similar to OECD 304A. Despite differences from the guideline, the
study is well described and the mass balance of applied test substance
is ~90 to 94%.
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