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EC number: 203-396-5
CAS number: 106-42-3
single-administration study, groups of five F344/N rats of each sex
received 500, 1,000, 2,000, 4,000, or 6,000 mg/kg. Administration of
mixed xylenes caused deaths at 6,000 mg/kg in each sex and at 4,000
mg/kg in males. Clinical signs observed within 24 hours of dosing at
4,000 mg/kg included prostration, muscular incoordination, and loss of
hind limb movement; these effects continued through the second week of
observation. The LD50 was 3523 mg/kg/bw for males and greater than 4000
mg/kg/bw for females.
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