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EC number: 203-396-5
CAS number: 106-42-3
acute datasets are available for each of the xylene isomers. Based on
the very similar physico-chemical properties of the isomers and the
similarity of the results from the acute ecotoxicity studies, we believe
that it is appropriate to combine the ecotoxicity data from the three
from chronic fish studies are available for p-xylene and mixed xylenes.
Data from chronic invertebrate and algal studies are available for m-
and p-xylene. Again, based on the very similar physico-chemical
properties of the isomers and the similarity of the results from the
chronic ecotoxicity studies, we believe that it is appropriate to
combine all the available data. This results in a chronic dataset of two
invertebrate studies, two fish studies, and a single algal study.
screening criteria for toxicity in the PBT assessment is that a
substance with an acute L(E)C50 <0.1 mg/L is considered to potentially
meet the T criterion and an L(E)C50 <0.01 mg/L indicates a substance is
definitely T. Chronic fish studies are available for p-xylene and mixed
xylenes and acute and chronic ecotoxicity data are available from
studies conducted with m, p and o-xylene. The most conservative results
are: 96 hour LC50 for fish is 2.6 mg/L for p-xylene (Galassi et al.
1988), 24 hour EC50 for invertebrates of 1 mg/L for o-xylene (Galassi et
al. 1988), 73 hour EC50 for algae of 4.36 mg/L for p-xylene (TNO, 2004),
35 day NOEC for fish of 0.714 mg/L for p-xylene (Noack, 2017), 7 day
NOEC for invertebrates of 1.17 mg/L for m-xylene (Niederlehner et al.
1998) and 73 hour NOEC for algae of 0.44 mg/L for p-xylene (TNO 2004).
All of the acute toxicity values are greater than the screening criteria
and the chronic toxicity values are greater than the criteria in Annex
XIII of the REACH regulations. Therefore, the xylene isomers are not
considered to be T.
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