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EC number: 203-396-5
CAS number: 106-42-3
The lowest 96 hour LC50 is 2.6 mg/L for p-xylene. The estimated LL50 values from TLM QSAR were 4.667 - 5.921 mg/L.
The lowest value was sued for chemical safety assessment.
Data are available on the acute toxicity of
each of the xylene isomers to fish. The studies by Galassi et al (1988),
Springborn (1994) and DiMarzio et al (2004) follow OECD 203, whilst
Holcombe et al (1987) used a flow through system to expose different
species simultaneously. Galassi et al (1988), Springborn (1994) and
Holcombe et al (1987) used a standard test species, whilst DiMarzio et
al (2004) tested a nonstandard freshwater fish. All studies included
analytical confirmation of the exposure concentrations.
The 96hr LC50 results reported from these
studies for the different isomers are very similar, with a range of 2.6
-11.23 mg/L. The most conservative result from the individual isomers
will be used in the risk assessment.
A TLM-EqP modeling framework was used to
support values derived experimentally and are presented as supporting
The estimated LL50 values from TLM QSAR were
4.667 - 5.921 mg/L.
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