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EC number: 216-721-0
CAS number: 1653-19-6
Table 1 - Exposure Data
DCBD Concentration (mg/L)
Ten male Crl:CD rates were exposed 6 hours/day, 5 days/week for 2 weeks
to 0.40 mg/L of DCBD in air. A control group was simultaneously exposed
to air only. During exposure, clinical observations of test rats were
indistinguishable from those of controls. Test rats had significantly
lower body weights than controls during the exposure period but showed a
normal rate of weight gain during the recovery period. Pathologic
examination showed no compound-related microscopic changes in rats
exposed to DCD. Microscopically, there was a slight increase in liver
mitotic figures following the 10th exposure. This change was not
observed following 14 days recovery. The significance of this change is
not clear since no other morphologic alterations were observed. The mean
relative liver weight of the test rats was significantly higher upon
comparison with controls after the 10th exposure but was in the normal
range after 14 days recovery. The mean relative testing weight of test
rats was significantly higher than that of controls after 14 days
recovery. In the absence of any microscopic changes, the relevance of
this weight change is questionable.
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