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EC number: 216-721-0
CAS number: 1653-19-6
There are no standard studies on the repeated dose toxicity of 2,3 dichloro-1,3 butadiene following oral or dermal exposures. No effects attributed to 2,3 dichloro-1,3 butadiene were observed in a sub-acute repeated dose inhalation study in which rats were exposed to vapours at 0.4 mg/l. In a one-generation, repeated dose inhalation exposures to 2,3 dichloro-1,3 butadiene at 0, 1, 5 or 50 ppm, A NOEL of 5 ppm (25 mg/m3) was reported based on observations of decreased body weight, weight gain and food consumption parameters and degeneration of the nasal olfactory epithelium at 50 ppm.
are no standard studies on the repeated dose toxicity of 2,3
dichloro-1,3 butadiene following oral or dermal exposures.
effects attributable to 2,3 dichloro-1,3 butadiene were observed in a
sub-acute repeated dose inhalation study, in which 10 male Crl:Cd rats
were exposed to vapours at a concentrations of 0.4 mg/l for 6 hours/day,
5 days/week for 2 weeks (control rats were simultaneously exposed to air
only). No effects on clinical parameters or microscopic changes were
observed in treated rats. Although liver mitotic parameters were
slightly increased following the 10th exposure, levels were normal
following 14 days of recovery. The significance of this change is not
clear since no other morphologic alterations were observed. The mean
relative liver weights of treated rats were significantly higher that
controls after the 10th exposure but were normal after 14 days of
recovery. Treated rats had significantly lower body weights than
controls during the exposure period, but showed a normal rate of weight
gain during recovery. The relative testing weights of test rats were
significantly higher than that of controls after 14 days recovery. In
the absence of any microscopic changes, the relevance of this weight
change is questionable
The sub-chronic repeated dose inhalation toxicity of 2,3 dichloro-1,3
butadiene was investigated in a one-generation fertility and early
embryonic developmental study in which groups of Crl:CD®(SD)IGS BR rats
(24/sex/concentration) were exposed by whole body inhalation to
vapours at 0, 1, 5, or 50 ppm. Rats were exposed for 6 hours/day during
premating (8 weeks; 5 days/week), during cohabitation of mating pairs
(up to 2 weeks, 7 days/week), and then post-cohabitation for males and
nonpregnant females (approximately 7 days, 7 days/week). The pregnant
dams were exposed from conception to implantation (days 0-7 of
gestation). In parental rats, no treatment-related effects were observed
on mortality, clinical parameters, oestrous cycle and sperm parameters,
mating, precoital interval and fertility, gross observations and organ
weights. Treatment-related effects evident at 50 ppm were decreased body
weight and weight gain, food consumption and efficiency and degeneration
of the nasal olfactory epithelium.
The no-observed-effect level (NOEL) for the sub-chronic repeated dose
inhalation toxicity of 2,3 dichloro-1,3 butadiene in rats was reported
as 5 ppm (25 mg/m3) based on observations of reduced body
weight, bodyweight gain and food consumption parameters and degeneration
of the nasal olfactory epithelial toxicity at 50 ppm.
There is insufficient evidence to classify 2,3 dichloro-1,3 butadiene
for repeated dose toxicity
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