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EC number: 216-721-0
CAS number: 1653-19-6
In rats and mice the LD50 was determined as 222 and 110 mg/kg bw,
respectively. Immediately after application of
2,3-dichlorobuta-1,3-diene of unknown purity the animals became slightly
more active followed quickly by depression, low mobility and
indifference to food and environmental stimuli. At 100 mg/kg bw and
above deaths occurred (80 % of the deaths during the first 2 days and 20
% during the next 3-4 days); 600 mg/kg bw were absolutely lethal.
Examination of animals which died during the first 2 days after
application revealed polyhemia of all internal organs. The liver was
nutmeg-like enlarged with a dark coloured central part and pale edges.
In most cases the spleen was dark brown coloured and enlarged with dull
edges. The stomach was full, dilated, and had the characteristic odour
of 2,3-dichlorobuta-1,3-diene. No significant pathological changes were
observed in the other organs. In the animals sacrificed at the end of
the observation period some enlargement of the spleen was observed
macroscopically while the other internal organs appeared normal.
Microscopic examination of the internal organs revealed deep or
superficial necrotic changes of the mucous envelope of the stomach with
polyhemia as well as protein and fatty dystrophy of the epithelial
tissues of the kidneys of the animals of the 500 and 600 mg/kg bw groups.
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