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Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
sub-chronic toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1972
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
publication
Title:
Toxicological characteristics of a new dichlorobutadien monomer for synthetic rubber
Author:
Khechumov SA, Gizhlaryan MS, Khechnumova RM
Year:
1972
Bibliographic source:
Toksikol Gig Neftekim Proizvod 2008-211 cited in Chem Abstr 80; 56221s (1974)

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
rats were exposed to 0.048 mg/liter of the test substance 4h/d over 3 months under static conditions using a 750 litre chamber
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
dichlorobutadiene monomer (no further data)

Test animals

Species:
rat

Results and discussion

Effect levels

Dose descriptor:
conc. level:
Effect level:
0.048 other: mg/l
Based on:
test mat.
Sex:
not specified
Basis for effect level:
other: An exposure for 4 h/day to 0.048 mg/l for 3 month produced a decrease in body weight, capability of swimming, and no. of erythrocytes, increased blood sugar, and decreased diuresis

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion