Registration Dossier
Registration Dossier
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EC number: 216-721-0 | CAS number: 1653-19-6
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1972
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological characteristics of a new dichlorobutadien monomer for synthetic rubber
- Author:
- Khechumov SA, Gizhlaryan MS, Khechnumova RM
- Year:
- 1 972
- Bibliographic source:
- Toksikol Gig Neftekim Proizvod 2008-211 cited in Chem Abstr 80; 56221s (1974)
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- rats were exposed to 0.048 mg/liter of the test substance 4h/d over 3 months under static conditions using a 750 litre chamber
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 2,3-dichlorobuta-1,3-diene
- EC Number:
- 216-721-0
- EC Name:
- 2,3-dichlorobuta-1,3-diene
- Cas Number:
- 1653-19-6
- Molecular formula:
- C4H4Cl2
- IUPAC Name:
- 2,3-dichlorobuta-1,3-diene
- Details on test material:
- dichlorobutadiene monomer (no further data)
Constituent 1
Test animals
- Species:
- rat
Results and discussion
Effect levels
- Dose descriptor:
- conc. level:
- Effect level:
- 0.048 other: mg/l
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: An exposure for 4 h/day to 0.048 mg/l for 3 month produced a decrease in body weight, capability of swimming, and no. of erythrocytes, increased blood sugar, and decreased diuresis
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
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