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EC number: 216-721-0
CAS number: 1653-19-6
toxicity in vitro
In a reverse mutation assay using 4 strains ofS.typhimurium(TA1535,
TA1537, TA98 and TA100) with and without metabolic activation (rat liver
S9 homegenates), 2,3 dichloro-1,3 butadiene (99% pure) was mutagenic in
strains TA1535 with metabolic activation and in strains TA100 and TA98
with and without metabolic activation.
Although the cytogenicity of 2,3 dichloro-1,3 butadiene has not been
assessed in vitro, negative responses were obtained a rat bone marrow
micronucleus study and it is not considered necessary to repeat the
investigation using an in vitro assay.
An HRPT assay of 2,3 dichloro-1,3 butadiene for gene mutation was
toxicity in vivo
2,3 dichloro-1,3 butadiene showed no clastogenic activity in vivo after
whole body exposures of rats to vapour concentrations of up to 200 ppm
(1020 mg/m3). Clear evidence of bone marrow and systemic toxicity were
observed at 200 ppm. No statistically significant increases in
micronucleated polychromatic erythrocytes in rat bone marrow where
observed in micronucleus assay in which rats were exposed by whole body
inhalation to 2,3 dichloro-1,3 butadiene at 0, 50, 100 and 200 ppm for 6
hours/day on two consecutive days.
Positive results obtained in bacterial mutagenicity tests suggest that
2,3 dichloro-1,3 butadiene may have some genotoxic potential in vitro,
with or without metabolic activation. However, negative results were
obtained in an in vivo bone marrow micronucleaus assay in which rats
were exposed to 2,3 dichloro-1,3 butadiene by inhalation. An HPRT
assay of 2,3 -dichlorobutadiene for gene mutation was also negative.
Overall, based on a weight-of-evidence consideration 2,3
dichloro-1,3 butadiene is judged as negative, and a classification of
2,3 dichloro-1,3 butadiene is not recommend.
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